Table Sequence and receptor specificity of α3/5 and other more unusual muscle-specific α-conotoxins. #, amidated C–terminus; ^, free carboxyl C–terminus; γ, γ–carboxyglutamate; O, 4–trans–hydroxyproline; Z, pyroglutamate. The cysteine residues that form the disulfide bridges are in bold.
From: Alpha-conotoxins as pharmacological probes of nicotinic acetylcholine receptors
Toxin | Sequence | Receptor | Reference |
|---|---|---|---|
α-CTx GI | ECCNPACGRHYSC# | Muscle | |
α-CTx GIA | ECCNPACGRHYSCGK# | Muscle | |
α-CTx GII | ECCNPACGKHFSC# | Muscle | |
α-CTx MI | GRCCHPACGKNYSC# | Muscle | |
α-CTx SI | ICCNPACGPKYSC# | Muscle | |
α-CTx SIA | YCCHPACGKNFDC# | Muscle | |
α-CTx SII | GCCCNPACGPNYGCGTSCS^ | Muscle | |
α-CTx CnIA | GRCCHPACGKYYSC# | Muscle, α7 | |
α-CTx CnIB | CCHPACGKYYSC# | Muscle | |
α-CTx Ac1.1a | NGRCCHPACGKHFNC# | Muscle | |
α-CTx Ac1.1b | NGRCCHPACGKHFSC# | Muscle | |
α-CTx EI | RDOCCYHPTCNMSNPQIC# | Muscle, α3β4, α4β2 (potentiation) | |
α-CTx SrIA | RTCCSROTCRMγYPγLCG# | Muscle, α4β2 (potentiation) | |
α-CTx SrIB | RTCCSROTCRMEYPγLCG# | Muscle, α4β2 (potentiation) | |
α-CTx PIB | ZSOGCCWNPACVKNRC# | Adult/fetal muscle |
