Abstract
Aim:
Genetic susceptibility is an important risk factor for aortic aneurysm and dissection. Recent case-control association studies have identified six single nucleotide polymorphisms (SNPs) associated with abdominal aortic aneurysm (AAA) in a Caucasian population. We aimed to determine whether these loci confer susceptibility to thoracic aortic dissection (TAD) in a Chinese Han population and thus to establish cross-race susceptibility to TAD.
Methods:
This study analyzed blood DNA isolated from 206 TAD patients and 180 controls from the ethnic Chinese Han population. Six SNPs – rs819146, rs8003379, rs2853523, rs326118, rs3788205, and rs10757278 – were genotyped using high-throughput matrix-assisted laser desorption ionization-time-of-flight (MALDI-TOF) mass spectrometry.
Results:
The A allele frequency for the SNP on 9p21, tagged as rs10757278, was higher in male TAD patients than in male controls (P=0.017). Moreover, with adjustment for traditional cardiovascular risk factors (sex, age, hypertension, dyslipidemia, diabetes, and smoking), the rs10757278 [odds ratio (OR) 0.63, 95% confidence interval (CI) 0.43 to 0.93] polymorphism was found to be an independent susceptibility factor for TAD in men.
Conclusion:
Our results suggest that a sequence variant on 9p21 is an important susceptibility locus that confers high cross-race risk for development of TAD in Chinese Han population.
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Acknowledgements
This work was supported by grants from the National Natural Science Foundation Council of China (No 30872536 and No 30888004), the Scientific Research Program of the Beijing Municipal Commission of Education (No KM200910025020), and the Chinese Ministry of Science and Technology (No 2009CB522205).
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Liu, O., Li, Jr., Gong, M. et al. Genetic analysis of six SNPs in candidate genes associated with high cross-race risk of development of thoracic aortic aneurysms and dissections in Chinese Han population. Acta Pharmacol Sin 31, 1376–1380 (2010). https://doi.org/10.1038/aps.2010.159
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DOI: https://doi.org/10.1038/aps.2010.159
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