Table 2 Mutation profile of six cell lines and five primary MM samples with respect to adhesion and RTK signaling

From: Multiple myeloma is affected by multiple and heterogeneous somatic mutations in adhesion- and receptor tyrosine kinase signaling molecules

Gene

AMO1

U266

OPM2

MM1S

JJN3

L363

Patient 1

Patient 2

Patient 3

Patient 4

Patient 5

MMP15

 

x(homoz.)

 

x

    

x

  

MUC4

    

xx (<2)

   

x

  

COL10A1

   

x

  

x

    

SDK1

    

x

 

x

    

LRFN5

 

x

 

x

  

x

    

THBS1

x

     

x

    

SLAMF1

      

x

    

COL6A3

  

xx

    

x

   

VCAN

      

x

    

THSD7A

      

x

    

ALOX12B

  

x (<2)

   

x

    

HSD17B1

       

x

   

NCAM2

      

x

    

ADAM29

 

x

 

x

       

ADAMTS1

x

          

ADAMTSL1

   

x(homoz.)

       

BCAN

x

 

x

        

COL17A1

   

x

       

COL7A1

   

x

       

DCHS1

 

x

 

x

       

DCHS2

   

x

       

ITGA10

 

x

 

x

       

ODZ1

   

x

       

SIGLEC1

   

x

       

WHSC1

   

x

       

LAMB2

   

x

       

PCDHGA7

 

x

 

xx

x

      

ADAMTS19

 

x (<2) x

         

ADAMTS9

x

          

CAMTA1

  

x

        

ADAMTS2

x (<2)

 

x

        

COL12A1

     

x

     

COL16A1

     

x

     

HS6ST3

 

x

 

x

       

LAMA5

  

x

x

       

NRXN1

     

x

     

ODZ4

     

x

     

PCDH10

x

          

ADAMTS18

  

x

        

CDH11

     

x

     

CELSR2

    

x

      

GPC6

x

  

x

       

ITGB1

 

x

         

LAMB1

     

x

     

PCDH15

    

x(homoz.)

      

PCDH17

    

x

      

PCDH20

x

          

RELN

 

xx

         

SPOCK1

  

x

        

TLN2

     

x

     

TNC

x

  

x (<2)

       

TGFBR2

      

x

    

CHIA

   

x(homoz.)

       

NTRK1

   

x

      

x

EPHB2

      

x

    

EPHA8

 

x

 

x

  

x

    

NTRK2

     

x

    

xx

EGFR

x

  

x

       

ERBB3

x

    

x

     

IGF1R

     

x

     

TTN

    

x (<2)

      

HK3

      

x

    

STAM2

      

x

    

IKBKE

      

x

    

ADRBK1

      

x

    

AKAP1

      

x

    

TYK2

   

x

       

KRAS

x

  

x

     

x

 

NRAS

     

x

     

BRAF

 

x

         

MAP2K2

x

     

x

    
  1. Abbreviations: MM, multiple myeloma; RTK, receptor tyrosine kinase; x, mutated; xx, mutated twice in the same sample; homoz., homozygous
  2. Adhesion molecules, RTKs and some downstream molecules are listed that were mutated in at least 1 of the5 primary MM or in at least 1 cell line, plus at least 1 of the 38 published primary MM.5 All mutations mentioned (x, xx, homoz.) were damaging in at least two functional predictors, if not otherwise specified (<2=less than 2 predictors). Genes that belonged to the same signaling network according to the STRING database or manual literature search were highlighted in bold and italics (bold: medium confidence; italics: low confidence). The mutation details for the 38 primary MM5 are shown in Supplementary Table S12.
Back to article page