Table 1 Patient characteristics
Variable | 1990–2000 Cohort (n=1208) | 2001–2012 cohort (n=2234) | P |
|---|---|---|---|
Male/Female | 628/580 | 1159/1075 | 0.96 |
Median age, years (range) | 70 (31–96) | 67 (26–96) | 0.062 |
Age⩾75 (%) | 354 (29.7) | 723 (32.4) | |
Performance status (%) | <0.001 | ||
 0 | 221 (18.6) | 305 (18.6) | |
 1 | 323 (27.2) | 602 (36.7) | |
 2 | 286 (24.1) | 396 (24.2) | |
 ⩾3 | 358 (30.1) | 336 (20.5) | |
 Unknown | 20 | 595 | |
M protein type (%) | 0.63 | ||
 IgG | 693 (58.0) | 1329 (60.0) | |
 IgA | 259 (21.7) | 415 (18.7) | |
 IgD | 42 (3.5) | 63 (2.8) | |
 Light chain | 155 (13.0) | 347 (15.6) | |
 Others | 44 (3.7) | 20 (0.9) | |
 Non-secretory | 1 (0.1) | 44 (2.0) | |
 Unknown | 14 | 16 | |
Durie & Salmon stage (%) | 0.16 | ||
 I | 111 (9.5) | 180 (8.4) | |
 II | 316 (27.1) | 546 (25.4) | |
 III | 741 (63.4) | 1424 (66.2) | |
 Unknown | 40 | 84 | |
ISS stage (%) | 0.02 | ||
 I | 290 (33.3) | 509 (26.5) | |
 II | 293 (33.6) | 750 (39.1) | |
 III | 288 (33.1) | 660 (34.4) | |
 Unknown | 337 | 315 | |
Hb (%) | 0.06 | ||
 Normal | 509 (43.3) | 941 (47.3) | |
 Low (<10 g/dl) | 667 (56.7) | 1048 (52.7) | |
 Unknown | 32 | 245 | |
Serum Cr (%) | 0.92 | ||
 Normal | 990 (84.7) | 1671 (84.5) | |
 High (>2 mg/dl) | 179 (15.3) | 307 (15.5) | |
 Unknown | 39 | 256 | |
Serum Ca (%) | 0.35 | ||
 Normal | 1032 (90.9) | 1631 (88.9) | |
 High (>11 mg/dl) | 103 (9.1) | 204 (11.1) | |
 Unknown | 73 | 399 | |
Serum LDH (%) | <0.001 | ||
 Normal | 971 (82.3) | 1434 (73.1) | |
 High (>normal upper limit) | 209 (17.7) | 528 (26.9) | |
 Unknown | 28 | 272 | |
Karyotype (%) | 0.15 | ||
 Normal | 228 (82.9) | 1149 (77.4) | |
 Abnormal | 47 (17.1) | 335 (22.6) | |
 Unknown | 933 | 750 |
