Abstract
Regressor serum from MSV-M-infected mice markedly reduced MSV-M oncogenesis when administered i.p. (0-1 ml/mouse) as much as 30 days before i.m. MSV-M infection in adult BALB/c mice. The regressor serum activity appeared to be directly dependent on the amount of IgG, as shown by: (1) inactivity of sera which have low virus-neutralizing antibody content, (2) high effectiveness only of the IgG serum fraction, (3) inactivity of regressor serum incubated with anti-mouse gamma-globulin serum. The regressor serum activity was specific and could not be ascribed to interferon or interferon-inducing factors, antigen-antibody complexes or free antigen. The activity was not suppressed by sublethal irradiation (380 rad) of recipient mice. These results suggest that the activity of regressor serum administered before MSV-M infection is mediated through sensitization of host cells which are not radiosensitive.
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Preliminary report presented to 11th International Cancer Congress, Florence, Italy, in October 1974.
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Guiliani, F., Casazza, A., Soranzo, C. et al. Effect of pretreatment with immune serum on murine sarcoma virus (Moloney) tumour induction and growth. Br J Cancer 35, 190–198 (1977). https://doi.org/10.1038/bjc.1977.26
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DOI: https://doi.org/10.1038/bjc.1977.26
