Table 2 Summary results for the six most significant SNPs in all EPICOLON phases

From: A two-phase case–control study for colorectal cancer genetic susceptibility: candidate genes from chromosomal regions 9q22 and 3q22

   

Discovery

 

Replication

 

Overall

 

SNP

Gene

Test

OR (95% CI)

P -value

OR (95% CI)

P -value

OR (95% CI)

P -value

rs1444601

TOPBP1

Geno

0.77 (0.59–1.00)

 

0.93 (0.76–1.14)

 

0.88 (0.75–1.03)

 
   

0.69 (0.42–1.13)

0.087

0.64 (0.43–0.97)

0.097

0.65 (0.48–0.89)

0.015

  

Allelic

0.80 (0.65–0.98)

0.028

0.86 (0.74–1.01)

0.070

0.84(0.75–0.95)

0.0054

  

Dom

0.76 (0.59–0.97)

0.030

0.88 (0.73–1.07)

>0.1

0.84 (0.72–0.98)

0.023

  

Rec

0.77 (0.47–1.24)

0.279

0.66 (0.45–0.99)

0.041

0.69 (0.51–0.94)

0.016

rs13088006

CDV3

Geno

1.05 (0.80–0.37)

 

0.83 (0.68–1.03)

 

0.92 (0.78–1.08)

 
   

0.55 (0.32–0.95)

0.067

0.73 (0.46–1.16)

>0.1

0.66 (0.47–0.92)

0.043

  

Allelic

0.88 (0.71–1.08)

0.222

0.84 (0.71–0.99)

0.042

0.87 (0.76–0.98)

0.025

  

Dom

0.96 (0.74–1.24)

0.715

0.82 (0.67–0.99)

0.049

0.88 (0.75–1.02)

0.098

  

Rec

0.54 (0.31–0.92)

0.022

0.78 (0.49–1.23)

>0.1

0.98 (0.48–0.95)

0.022

rs939453

ARMC8

Geno

0.68 (0.51–0.90)

 

1.10 (0.88–1.38)

 

1.10 (0.71–1.01)

 
   

0.62 (0.43–0.89)

0.017

1.07 (0.81–1.41)

>0.1

0.79 (0.64–0.98)

0.068

  

Allelic

0.78 (0.65–0.93)

0.0056

0.96 (0.84–1.1)

>0.1

0.89 (0.80–0.99)

0.025

  

Dom

1.47 (1.11–1.93)

0.0062

0.91 (0.74–1.13)

>0.1

0.83 (0.71–0.98)

0.27

  

Rec

0.77 (0.56–1.04)

0.091

0.99 (0.78–1.25)

>0.1

0.88 (0.73–1.05)

0.163

rs1131597

SLCO2A1

Geno

0.77 (0.59–1.01)

 

0.97 (0.79–1.19)

 

0.97 (0.76–1.04)

 
   

0.47 (0.31–0.72)

0.0015

1.07 (0.79–1.47)

>0.1

0.80 (0.63–1.02)

>0.1

  

Allelic

0.71 (0.59–0.86)

0.00038

1.02 (0.88–1.17)

>0.1

0.89 (0.80–0.99)

0.043

  

Dom

0.70 (0.54–0.90)

0.005

0.99 (0.82–1.20)

>0.1

0.88 (0.75–1.01)

0.068

  

Rec

0.54 (0.36–0.81)

0.0026

1.09 (0.81–1.46)

>0.1

0.85 (0.67–1.07)

0.164

rs10934954

PIK3R4

Geno

1.13 (0.86–1.47)

 

0.93 (0.75–1.15)

 

1.01 (0.85–1.18)

 
   

1.95 (1.09–3.51)

0.068

1.25 (0.79–1.98)

>0.1

1.50 (1.05–2.13)

0.081

  

Allelic

1.25 (1.01–1.54)

0.042

1.01 (0.87–1.15)

>0.1

1.10 (0.97–1.25)

>0.1

  

Dom

1.21 (0.94–1.56)

0.146

0.97 (0.79–1.18)

>0.1

1.06 (0.91–0.24)

0.450

  

Rec

1.87 (1.05–3.34)

0.031

1.28 (0.82–2.02)

>0.1

1.49 (1.05–2.12)

0.025

rs2071387

RBP1

Geno

1.17 (0.89–1.55)

 

1.02 (0.82–1.26)

 

1.04 (0.88–1.23)

 
   

0.38 (0.17–0.87)

0.023

1.40 (0.81–2.43)

>0.1

0.57 (0.36–0.90)

0.034

  

Allelic

0.95 (0.75–1.20)

0.672

0.93 (0.78–1.11)

>0.1

0.93 (0.81–1.07)

>0.1

  

Dom

1.06 (0.81–1.39)

0.662

0.95 (0.77–1.17)

>0.1

0.98 (0.84–1.15)

>0.1

  

Rec

0.37 (0.16–0.83)

0.012

0.72 (0.42–1.24)

>0.1

0.56 (0.36–0.88)

0.010

  1. Abbreviations: CI=confidence interval; Dom=dominant; Geno=genotypic; OR=odds ratio; Rec=recessive; SNP=single-nucleotide polymorphism.
  2. ORs and unadjusted P-values are shown for discovery, replication and overall phases for each of them. Significant P-values are depicted in bold.
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