Table 1 Univariate and multivariate Cox regression analysis of progression-free survival for patients with non-muscle-invasive tumours

From: Low ANXA10 expression is associated with disease aggressiveness in bladder cancer

  

Univariate analysis

Multivariate analysis

Variables

Categorisation

Hazard ratio

P -value

Hazard ratio

P -value

Age

5-year interval

1.18 (1.06–1.32)

0.003

1.09 (0.97–1.22)

0.128

Sex

Male vs female

0.92 (0.56–1.51)

0.755

  

Tumour stage

Ta vs T1

2.58 (1.73–3.85)

<0.0001

0.82 (0.33–2.00)

0.661

Histological grade

PUNLMP/low vs high

3.02 (2.02–4.51)

<0.0001

2.92 (1.17–7.28)

0.021

Tumour size

<3 vs >3 cm

0.97 (0.60–1.56)

0.900

  

BCG treatment

No BCG vs BCG

0.57 (0.32–1.01)

0.055

0.47 (0.25–0.89)

0.020

Concomitant CISa

No CIS vs CIS

1.41 (0.94–2.12)

0.098

1.13 (0.71–1.80)

0.601

Growth pattern

Papillary vs solid

2.71 (1.40–5.25)

0.003

1.56 (0.79–3.09)

0.201

ANXA10 nuclear %

Low vs medium

0.49 (0.30–0.80)

0.005

0.59 (0.34–1.02)

0.058

 

Low vs high

0.25 (0.13–0.50)

<0.0001

0.35 (0.17–0.70)

0.003

  1. Abbreviation: BCG=Bacillus Calmette-Geurin; CIS=carcinoma in situ; PUNLMP=papillary urothelial neoplasm of low malignant potential.
  2. aThree samples without information about CIS status were excluded.
  3. Only variables with P<0.1 in univariate analysis were included in the multivariate analysis.