Figure 5 | British Journal of Cancer

Figure 5

From: Exon-array profiling unlocks clinically and biologically relevant gene signatures from formalin-fixed paraffin-embedded tumour samples

Figure 5

Cross-validation of the FFPE-derived gene signature on an independent fresh-frozen NSCLC data set. (A) Hierarchical clustering of genes and samples was based on Pearson's correlation. The scaled expression of each probeset, denoted as the row Z-score, is plotted in red–blue colour scale with red indicating high expression and blue indicating low expression. The coloured bar above the heatmap indicates the histological classification: orange=SCC; green=AC; blue=misclassified samples. (B) Principal component analysis of the SCC/AC gene signature when applied to the NSCLC data set. The numbers represent the patient IDs. Different colours are used to represent the different histological subtypes: orange=SCC; green=AC; blue=misclassified samples. (C) Percentage variance explained by the first 10 principal components.

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