Table 4 CD151 expressions and positive rates in variable epithelial malignancy as measured by the immunohistochemical method
From: Clinical significance of CD151 overexpression in subtypes of invasive breast cancer
| Â | Country | Year | Organ | Cancer type | Number | Tissue | Antibody | Titer | Incubation | % positive | Cutoff of positive cases | Survival data | Multivariate data |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1. This study | Korea | 2011 | Breast | Invasive carcinoma | 886 | FFPE, TMA | RLM30, Novocastra | 1 : 100 | 2 h, RT | 14.6 | 3+ with diffuse complete membrane stating | Yes | Yes |
2. Yang et al (2008) | USA | 2008 | Breast | Invasive ductal carcinoma | 124 | FFPE, TMA | RLM30, Novocastra | 1 : 50 | NA | 31.0 | 2+ or 3+ | None | None |
UK | 2009 | Breast | Invasive ductal carcinoma | 56 | FFPE | RLM30, Novocastra | 1 : 50 | NA | 30.4 | >10% of positive cells with weak to strong complete membrane staining | Yes | None | |
4. Voss et al (2011) | UK | 2011 | Uterus | Endometrial cancer | 131 | FFPE, TMA | RLM30, Novocastra | 1 : 50 | NA | 58.7 | >H-score 150 | Yes | Yes |
Korea | 2011 | Kidney | Clear cell carcinoma | 489 | FFPE, TMA | RLM30, Novocastra | 1 : 100 | 1 h, RT | 47.5 | >50% of positive cells with diffuse moderate or strong intensity | Yes | Yes | |
Japan | 2010 | Esophagus | Squamous cell carcinoma | 138 | FFPE | RLM30, Novocastra | 1 : 50 | 4°C overnight | 54.3 | >10% of positive cells with weak to strong complete membrane staining | Yes | No | |
China | 2010 | Liver | Intrahepatic cholangiocarcinoma | 140 | FFPE, TMA | 11G5a, Serotec | 1 : 200 | NA | 53.6 | >50% of tumour cells | Yes | Yes | |
8. Ke et al (2009) | China | 2009 | Liver | Hepatocellular carcinoma | 520 | FFPE, TMA | 11G5a, Serotec | 1 : 100 | NA | 59.8 | >50% of tumour cells | Yes | Yes |
9. Zhu et al (2011) | China | 2011 | Pancreas | Ductal adenocarcinoma | 71 | FFPE | sc-80715, Santa Cruz | 1 : 00 | 1 h, RT | 81.7 | 4–7 points, moderate to strong intensity | Yes | Yes |
10. Ang et al (2004) | Australia | 2004 | Prostate | Adenocarcinoma | 76 | FFPE | 11B1, purified IgG2a | 4 ug ml−1 | 2 h, RT | 23.0 | >17.52 density and area measured by digitised imagea | Yes | None |
11. Hashida et al (2003) | Japan | 2003 | Colon | Adenocarcinoma | 146 | Frozen sections | SFA1.2B4 | NA | 2 h, RT | 55.5 | >120 multiplying of intensity and percentage of cells | Yes | Yes |
12. Tokuhara et al (2001) | Japan | 2001 | Lung | Non-small cell carcinoma | 145 | Frozen sections | SFA1.2B4 | NA | 2 h, RT | 54.5 | >50% of tumour cells | Yes | Yes |
