Figure 3
From: FADD protein release mirrors the development and aggressiveness of human non-small cell lung cancer
Fas-associated death domain protein release is correlated with cancer development. (A–C) Fas-associated death domain protein release is correlated with patients' cancer stage. Levels of released FADD determined in Figure 2B were reanalysed after the 50 NSCLC patients were classified according to their cancer stage. Each diamond represents a patient biopsy (T in black, NT in white). Bars represent the mean value. P values were determined using the Wilcoxon signed-rank test (A). Histograms represent the mean released FADD value ±s.e.m. P values were determined using the Mann–Whitney test (B). (D) Patient 89 is a 54-year-old smoking (60 pack per year) man. Surgical resection of brain metastasis was performed in 2007, followed by 2 years of radiotherapy and chemotherapy. Fas-associated death domain protein release by remitted tumour (dark grey) and adjacent parenchyma (light grey) biopsies following 1-h in vitro culture was determined by ELISA, and was compared with the mean level of FADD released by the 50 NSCLC T (black) and NT (white) biopsies. Abbreviation: NS=not significant.
