Table 5 Accelerated-failure time model

From: Long-term survival after treatment for Hodgkin’s disease (1973–2002): improved survival with successive 10-year cohorts

Factor

Time ratio univariate

95% CI

Time ratio multivariate

95% CI

P -value

Cohort

 Cohort(73–82)

1.00

 

1.00

  

 Cohort(83–92)

4.85***

1.93, 12.22

1.92*

1.02, 3.62

0.045

 Cohort(93–02)

22.58***

8.84, 57.71

4.60***

2.28, 9.30

<0.001

Age group

 Age gp (<26)

1.00

 

1.00

  

 Age gp(26–45)

0.64

0.26, 1.57

0.81

0.39, 1.66

0.556

 Age gp(46–65)

0.07***

0.03, 0.18

0.14***

0.06, 0.30

<0.001

 Age gp(66+)

0.004***

0.001, 0.011

0.02***

0.01, 0.06

<0.001

Gender

 Male

1.00

 

1.00

0.85, 2.51

 

 Female

1.26

0.51, 3.13

1.46

0.85, 2.51

0.170

Treatment

 Chemotherapy

1.00

 

1.00

  

 Combi (chemo+radio)

23.22***

9.36, 57.65

2.06

0.99, 4.28

0.053

 Radiotherapy

27.14***

11.83, 62.28

2.63*

1.24, 5.57

0.011

B symptom

 No

1.00

 

1.00

  

 Yes

0.39*

0.17, 0.91

0.42**

0.23, 0.76

0.005

Who

 Lymphocyte

1.00

 

1.00

  

 Mixed Cell

0.22*

0.06, 0.88

0.31*

0.11, 0.85

0.022

 Nodular Scl

0.49

0.14, 1.75

0.37*

0.15, 0.92

0.032

 Unspecified

0.001***

0.0003, 0.008

0.03***

0.01, 0.14

<0.001

Stages

 Stage I

1.00

 

1.00

  

 Stage II

0.33*

0.13, 0.83

0.37*

0.16, 0.84

0.018

 Stage III

0.06***

0.02, 0.15

0.29**

0.12, 0.68

0.005

 Stage IV

0.02***

0.006, 0.089

0.22**

0.08, 0.63

0.005

 Stage V

0.001***

0.0004, 0.004

0.06***

0.01, 0.26

<0.001

  1. *P<0.05, **P<0.01, ***P<0.001. If TR<1, event occurs faster as time accelerates. If TR>1, event delays as time decelerates.