Figure 3

Investigator-assessed tumour regression (i.e., maximum change from baseline in target lesions diameter). (n=27) Patients with RECIST progressive disease are indicated by an asterix. Clear grey: AUCmax <100 mg l⁻¹ h⁻¹; dark grey: AUCmax⩾100 mg l⁻¹ h⁻¹.