Table 3 Parameters associated with time to disease progression by uni- and multivariate analysis (Cox proportional hazards model)

	N	Univariate HR	95% CI	P -value	Multivariate HR	95% CI	P -value
WHO PS
0–1	22	1
2–3	6	1.77	0.62–4.35	0.26
Time from metastatic diagnosis
⩽15 Months	9	1
>15 Months	19	0.47	0.18–1.17	0.10^a	—	—	NS
Early hypertension
Grade<2	17	1
Grade⩾2	11	0.92	0.28–1.49	0.31
Early HFSR
Grade<2	14	1
Grade⩾2	14	0.65	0.32–1.75	0.49
Early rash
Grade<2	7	1
Grade⩾2	21	0.44	0.10–1.37	0.17^a	—	—	NS
Early diarrhoea
Grade<2	19	1
Grade⩾2	9	0.51	0.19–1.23	0.13^a	—	—	NS
Early toxicities
Grade<2	8	1
Grade⩾2	20	0.38	0.15–0.98	0.045 ^a	—	—	NS
AUC max
<100	12	1			1
⩾100	15	0.28	0.11–0.72	0.009 ^a	0.28	0.11–0.72	0.009 ^a

Abbreviations: AUC=area under the plasma concentration–time curve over 12 h; CI=confidence interval; HFSR=hand-foot skin reaction; HR=hazard ratio; N=number of patients; NS=variables not selected by the stepwise multivariate model; PS=performance status.
Early toxicities included: hypertension, HFSR and diarrhoea during the first 2 months.
^aVariables included in the stepwise multivariate model. P-values <0.05 are in bold.

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