Figure 5 | British Journal of Cancer

Figure 5

From: Immunohistochemical markers of the hypoxic response can identify malignancy in phaeochromocytomas and paragangliomas and optimize the detection of tumours with VHL germline mutations

Figure 5

Possible algorithm incorporating CaIX immunohistochemical test (CaIX IHC) for genetic testing for PCC/PGL. A positive CaIX immunohistochemistry result should direct the clinician or the geneticist to perform a confirmatory VHL mutation test first, avoiding indiscriminate testing for all the four susceptibility loci.

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