Table 1 KRAS mutation status and relationship with clinicopathological variables and mismatch repair status in the Leeds and Yokohama gastric cancer cohort
Leeds gastric cancer | Yokohama gastric cancer | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Total | KRAS wild-type | KRAS mutated | Total | KRAS wild-type | KRAS mutated | |||||||||
n | % | n | % | n | % | P -value | n | % | n | % | n | % | P -value | |
Age group | ||||||||||||||
<70 years | 112 | 41 | 107 | 96 | 5 | 4 | 0.434 | 161 | 70 | 157 | 97 | 4 | 3 | 0.034 |
⩾70 years | 164 | 59 | 153 | 93 | 11 | 7 | 69 | 30 | 63 | 91 | 6 | 9 | ||
Gender | ||||||||||||||
Male | 164 | 59 | 155 | 95 | 9 | 5 | 0.791 | 162 | 70 | 155 | 96 | 7 | 4 | 0.975 |
Female | 112 | 41 | 105 | 94 | 7 | 6 | 68 | 30 | 65 | 96 | 3 | 4 | ||
Tumour location | ||||||||||||||
Proximal | 66 | 24 | 64 | 97 | 2 | 3 | 0.421 | 69 | 30 | 67 | 97 | 2 | 3 | 0.693 |
Mid | 72 | 26 | 66 | 92 | 6 | 8 | 93 | 40 | 89 | 96 | 4 | 4 | ||
Distal | 122 | 45 | 115 | 94 | 7 | 6 | 68 | 30 | 64 | 94 | 4 | 6 | ||
Stump | 8 | 3 | 7 | 88 | 1 | 12 | 0 | 0 | 0 | 0 | 0 | 0 | ||
L. plastica | 5 | 2 | 5 | 100 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | ||
Depth of invasion (pT) | ||||||||||||||
pT1a/b | 20 | 7 | 18 | 90 | 2 | 10 | 0.735 | 8 | 4 | 8 | 100 | 0 | 0 | 0.214 |
pT2 | 23 | 8 | 23 | 100 | 0 | 0 | 42 | 18 | 38 | 91 | 4 | 9 | ||
pT3 | 80 | 29 | 74 | 93 | 6 | 7 | 30 | 13 | 30 | 100 | 0 | 0 | ||
pT4a/b | 153 | 55 | 145 | 95 | 8 | 5 | 150 | 65 | 144 | 96 | 6 | 4 | ||
Lymph node status (pN) | ||||||||||||||
pN0 | 85 | 31 | 76 | 89 | 9 | 11 | 0.005 | 40 | 17 | 40 | 100 | 0 | 0 | 0.160 |
pN1 | 51 | 19 | 48 | 94 | 3 | 6 | 55 | 24 | 51 | 93 | 4 | 7 | ||
pN2 | 54 | 20 | 50 | 93 | 4 | 7 | 62 | 27 | 61 | 98 | 1 | 2 | ||
pN3a/b | 84 | 31 | 84 | 100 | 0 | 0 | 73 | 32 | 68 | 93 | 5 | 7 | ||
Grade of differentiation | ||||||||||||||
G1 | 31 | 11 | 28 | 90 | 3 | 10 | 0.768 | 23 | 10 | 20 | 87 | 3 | 13 | 0.063 |
G2 | 88 | 32 | 84 | 96 | 4 | 4 | 53 | 23 | 50 | 94 | 3 | 6 | ||
G3 | 156 | 57 | 147 | 94 | 9 | 6 | 154 | 67 | 150 | 97 | 4 | 3 | ||
Laurén classification | ||||||||||||||
Intestinal | 178 | 65 | 165 | 93 | 13 | 7 | 0.150 | 120 | 52 | 117 | 97 | 3 | 3 | 0.151 |
Diffuse | 60 | 22 | 58 | 97 | 2 | 3 | 110 | 48 | 103 | 94 | 7 | 6 | ||
Mixed | 38 | 14 | 37 | 97 | 1 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | ||
Mismatch repair status | ||||||||||||||
Proficient | 239 | 91 | 228 | 96 | 11 | 4 | 0.002 | 209 | 91 | 202 | 97 | 7 | 3 | 0.019 |
Deficient | 25 | 9 | 20 | 80 | 5 | 20 | 21 | 9 | 18 | 86 | 3 | 14 | ||
