Table 2 Univariate Cox regression analysis of bone markers in renal cell carcinoma after 18 months of ZOL treatment

From: Biochemical markers of bone turnover and clinical outcome in patients with renal cell and bladder carcinoma with bone metastases following treatment with zoledronic acid: The TUGAMO study

Variable	HR	95% CI (HR)	P-value
Death
Abnormal baseline β-CTX levels (>0.548 ng ml⁻¹)	2.834	1.076–7.465	0.035^a
High baseline β-CTX levels (>0.7 ng ml⁻¹, ROC cutoff)	6.146	2.223–16.990	<0.001^a
No normalisation of β-CTX levels in v₁^b	—	—	—
Abnormal baseline BALP levels (>15 UI l⁻¹)	1.226	0.475–3.165	0.674
High baseline BALP levels (>17.9 UI l⁻¹, ROC cutoff)	0.886	0.35–2.24	0.798
No normalisation of BALP levels in v₁	2.283	0.54–9.662	0.262
Abnormal baseline PINP levels (>62 ng ml⁻¹)	1.644	0.655–4.123	0.29
High baseline PINP levels (>110.3 ng ml⁻¹, ROC cutoff)	2.810	0.903–8.747	0.074
No normalisation of PINP levels in v₁	2.511	0.614–10.275	0.2
Disease progression
Abnormal baseline β-CTX levels (>0.548 ng ml⁻¹)	4.036	1.364–11.938	0.012^a
High baseline β-CTX levels (>0.641 ng ml⁻¹, ROC cutoff)	8.055	2.524–25.71	<0.001^a
No normalisation of β-CTX levels in v₁^b	—	—	—
Abnormal baseline BALP levels (>15 UI l⁻¹)	1.028	0.355–2.976	0.96
High baseline BALP levels (>12.4 UI l⁻¹, ROC cutoff)	1.981	0.549–7.151	0.296
No normalisation of BALP levels in v₁	1.097	0.227–5.315	0.908
Abnormal baseline PINP levels (>62 ng ml⁻¹)	1.681	0.589–4.793	0.331
High baseline PINP levels (>87.5 ng ml⁻¹, ROC cutoff)	1.723	0.599–4.957	0.312
No normalisation of PINP levels in v₁	2.523	0.709–8.982	0.153
Skeletal-related events
Abnormal baseline β-CTX levels (>0.548 ng ml⁻¹)	0.881	0.268–2.897	0.834
High baseline β-CTX levels (>0.157 ng ml⁻¹, ROC cutoff)	2.992	0.386–23.211	0.294
No normalisation of β-CTX levels in v₁^b	—	—	—
Abnormal baseline BALP levels (>15 UI l⁻¹)	2.107	0.694–6.393	0.188
High baseline BALP levels (>95.1 UI l⁻¹, ROC cutoff)	3.634	1.071–12.323	0.038^a
No normalisation of BALP levels in v₁	3.050	0.699–13.303	0.138
Abnormal baseline PINP levels (>62 ng ml⁻¹)	3.155	0.91–10.934	0.070
High baseline PINP levels (>53 ng ml⁻¹, ROC cutoff)	3.253	0.886–11.939	0.075
No normalisation of PINP levels in v₁	1.99	0.559–7.079	0.288

Abbreviations: BALP=bone alkaline phosphatase; β-CTX=beta-isomer of carboxy-terminal telopeptide of type I collagen; CI=confidence interval; HR=hazard ratio; PINP=procollagen type I amino-terminal propeptide; ROC=receiver operating characteristic; v₁=visit 1; ZOL=zoledronic acid.
Relative changes between v₁ and v₀ did not show statistically significant results, and they are not shown.
^aStatistically significant results.
^bThere were no patients with abnormal levels in v₁.

Back to article page

Table 2 Univariate Cox regression analysis of bone markers in renal cell carcinoma after 18 months of ZOL treatment

Search

Quick links