Table 2 The cutoff points and outcome for 23 immunomakers and 7 clinicopathological variables in predicting postoperative distant organ metastasis in the training cohort (n=319)

From: Support vector machine-based nomogram predicts postoperative distant metastasis for patients with oesophageal squamous cell carcinoma

  

95% CI

 

Variables

RR

Upper

Lower

P- value

Gender (male vs female)

2.484

1.397

4.415

<0.001

Age (⩽60 vs >60 years)

0.774

0.551

1.087

0.143

Tumour location (upper and middle vs lower third)

0.814

0.579

1.144

0.256

Cell differentiation (G1–2 vs G3)

0.457

0.332

0.630

<0.001

Tumour length (⩽2.5 vs >2.5 cm)

0.428

0.220

0.832

0.005

pT categories (T1–2 vs T3–4)

0.477

0.321

0.707

<0.001

pN categories (N0 vs N1–3)

0.333

0.239

0.465

<0.001

Angiogenesis ( n)

b-FGF (⩽2.33 (264) vs >2.33 (55))

1.190

0.731

1.939

0.473

Cox-2 (⩽1.33 (253) vs >1.33 (66))

0.557

0.397

0.781

0.001

VEGF (⩽1.33 (69) vs >1.33 (250))

0.530

0.308

0.914

0.013

Apoptosis ( n)

Bcl-2 (⩽5 (270) vs >5 (49))

0.716

0.480

1.070

0.120

NF-κB (⩽5 (174) vs >5 (145))

0.302

0.202

0.451

<0.001

Survivin (⩽9.33 (278) vs >9.33 (41))

0.919

0.566

1.493

0.736

Cell adhesion molecules ( n)

CD44ν6 (⩽10 (201) vs >10 (118))

0.759

0.541

1.064

0.113

E-cadherin (⩽2.67 (142) vs >2.67 (177))

1.301

0.927

1.825

0.128

Integrin β1 (0 (238) vs >0 (81))

2.121

1.250

3.597

0.002

Cell cycle regulators ( n)

Cyclin B1 (⩽6 (281) vs >6 (38))

4.102

1.367

12.312

0.002

Cyclin D1 (⩽3.33 (183) vs >3.33 (186))

0.600

0.427

0.844

0.003

Ki67 (⩽7 (256) vs >7 (63))

0.580

0.411

0.820

0.004

p21Waf1/Cip1 (⩽8.67 (183) vs >8.67 (136))

0.332

0.227

0.484

<0.001

DNA repair ( n)

ERCC1 (0 (255) vs >0 (64))

1.322

0.819

2.134

0.237

EGFR ( n)

EGFR (⩽6 (119) vs >6 (200))

2.370

1.684

3.336

<0.001

HER2/neu (⩽6 (231) vs >6 (88))

0.415

0.301

0.572

<0.001

MMP and inhibitors ( n)

MMP-1 (⩽3 (190) vs >3 (129))

1.380

0.956

1.992

0.079

MMP-11 (⩽3.33 (145) vs >3.33 (174))

1.252

0.892

1.758

0.193

TIMP-2 (⩽8 (294) vs >8 (25))

2.579

0.880

7.559

0.046

uPAR (⩽2.33 (200) vs >2.33 (119))

1.735

1.158

2.600

0.005

Tumour suppressor genes ( n)

NM23-H1 (0 (287) vs >0 (32))

2.509

0.987

6.374

0.026

P53 (⩽10.33 (167) vs >10.33 (152))

1.177

0.835

1.659

0.351

Rb (⩽0 (299) vs >0 (20))

0.562

0.350

0.903

0.037

  1. Abbreviations: b-FGF=basic fibroblast growth factor; CI=confidence interval; Cox-2=cyclo-oxygenase-2; EGFR=epidermal growth factor receptors; ERCC1=excision repair cross-complemention group 1; G1=well differentiated; G2=moderately differentiated; G3=poorly differentiated; MMP=matrix metalloproteinases; RR=relative risk; TIMP2=tissue inhibitors of metalloproteinases-2; uPAR=urokinase-type plasminogen activator receptor; VEGF=vascular endothelial growth factor.
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