Table 3 The cutoff points and outcome for 12 immunomakers and 7 clinicopathological variables in predicting postoperative distant organ metastasis in the validation cohort (n=164)

From: Support vector machine-based nomogram predicts postoperative distant metastasis for patients with oesophageal squamous cell carcinoma

  

95% CI

 

Variables

RR

Upper

Lower

P- value

Gender (male vs female)

1.154

0.804

1.657

0.427

Age (⩽60 vs >60 years)

0.957

0.667

1.372

0.812

Tumour location (upper and middle vs lower third)

0.834

0.601

1.157

0.283

Cell differentiation (G1–2 vs G3)

0.485

0.367

0.640

<0.001

Tumour length (⩽2.5 vs >2.5 cm)

0.403

0.205

0.793

0.001

pT categories (T1–2 vs T3–4)

0.695

0.354

1.365

0.241

pN categories (N0 vs N1–3)

0.449

0.336

0.598

<0.001

Angiogenesis ( n)

Cox-2 (⩽1.33 (144) vs >1.33 (20))

0.741

0.496

1.107

0.191

VEGF (⩽1.33 (32) vs >1.33 (132))

0.354

0.169

0.740

<0.001

Apoptosis ( n)

NF-κB (⩽5 (124) vs >5 (40))

0.553

0.410

0.747

0.001

Cell adhesion molecules ( n)

Integrin β1 (0 (104) vs >0 (60))

1.731

1.148

2.610

0.004

Cell cycle regulators ( n)

Cyclin B1 (⩽6 (145) vs >6 (19))

1.292

0.700

2.384

0.377

Cyclin D1 (⩽3.33 (89) vs >3.33 (75))

0.613

0.438

0.858

0.004

Ki67 (⩽7 (128) vs >7 (36))

0.690

0.496

0.960

0.044

p21Waf1/Cip1 (⩽8.67 (113) vs >8.67 (51))

0.558

0.410

0.759

<0.001

EGFR ( n)

EGFR (⩽6 (111) vs >6 (53))

1.539

1.016

2.331

0.028

HER2/neu (⩽6 (85) vs >6 (79))

0.512

0.359

0.731

<0.001

MMP and inhibitors ( n)

uPAR (⩽2.33 (99) vs >2.33 (65))

1.970

1.302

2.981

<0.001

Tumour suppressor genes ( n)

NM23-H1 (0 (151) vs >0 (13))

1.550

0.674

3.562

0.241

  1. Abbreviations: b-FGF=basic fibroblast growth factor; CI=confidence interval; Cox-2=cyclo-oxygenase-2; EGFR=epidermal growth factor receptors; ERCC1=excision repair cross-complemention group 1; G1=well differentiated; G2=moderately differentiated; G3=poorly differentiated; MMP=matrix metalloproteinases; RR=relative risk; TIMP2=tissue inhibitors of metalloproteinases-2; uPAR=urokinase-type plasminogen activator receptor; VEGF=vascular endothelial growth factor.
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