Figure 2

Categorisation of individual lesions into four response subgroups. Waterfall plot shows the percentage change in lesion size (black) and the percentage change in normalised mean enhancement (nE; red) between the baseline and the first on-treatment scan for each of the 56 lesions in the study. Criteria based on the change in size and the change in nE are used to classify response: response subgroup 1 (⩾30% reduction in size and ⩾50% reduction in enhancement), response subgroup 2 (<30% reduction in size, but <20% increase in size and ⩾50% reduction in enhancement), response subgroup 3 (<30% reduction in size, but <20% increase in size and <50% reduction in enhancement) and response subgroup 4 (⩾30% increase in size and <50% reduction in nE).