Figure 6

Diagrams illustrating the initial response to therapy and acquired resistance to therapy. (A–D) Diagram illustrating how individual lesions may be classified into response subgroups based on the vascular response and change in size after treatment with anti-angiogenic therapy. (A) Response subgroup 1: significant vascular response and significant tumour shrinkage. (B) Response subgroup 2: significant vascular response and stabilisation of disease. (C) Response subgroup 3: poor vascular response and stabilisation of disease. (D) Response subgroup 4: poor vascular response and progression of disease. (E and F) Diagram illustrating that acquired resistance to anti-angiogenic therapy is associated with rebound re-vascularisation. However, rebound re-vascularisation may be more aggressive in lesions having PR as best response (E) when compared with lesions having SD as best response (F).