Table 2 Treatment setting and dosing regimen

From: Changes in tumour vessel density upon treatment with anti-angiogenic agents: relationship with response and resistance to therapy

Drug

n

Manufacturer

Trial

Dose received

Schedule

Sunitinib

10

Pfizer

NA

50 mg od

28d on/14d off

Sunitinib

3

Pfizer

COMPARZ (NCT00720941)

50 mg od

28d on/14d off

Sunitinib

1

Pfizer

TRIST (NCT00397345)

50 mg od

28d on/14d off

Pazopanib

5

GlaxoSmithKline

COMPARZ (NCT00720941)

800 mg od

Continuous

Cediranib

2

Astra Zeneca

D8480C00030 (NCT00423332)

45 mg od

Continuous

Regorafenib

2

Bayer Healthcare Pharmaceuticals

DAST (NCT00664326)

160 mg od

21d on/7d off

  1. Abbreviations: d=days; NA=not applicable; od=oral dose.