Figure 3
From: Radiation-induced non-targeted response in vivo: role of the TGFβ-TGFBR1-COX-2 signalling pathway
TGF- β but not TNF- α is induced in bystander lung tissues after lower abdominal irradiation. (A) Western blot data show expression of TGF-β and TNF-α in non-targeted lung tissues as a function of day postirradiation. Quantification of relative fold changes of TGF-β and TNF-α expression relative to β-actin of each group is shown. (B) Similar to A, but showing expression levels of TGFBR1 and TGFBR2 in non-targeted lung tissues at different time points postirradiation. (C) Western blot data showing expression levels of TNF-α and TNF-α receptor 1 in bystander lung tissue as a function of time post-irradiation. β-actin levels were used as a loading control. (D) Different expression level of TGFBR1 in lung and liver tissues. Lungs and livers are from three independent non-irradiated animals from control group.
