Figure 4
From: Radiation-induced non-targeted response in vivo: role of the TGFβ-TGFBR1-COX-2 signalling pathway
Differential distribution of TGF- β and TGFBR1 in non-targeted lung tissues. (A) Representative immunohistochemical staining of TGF-β in lung tissue section of animals irradiated with a whole-body dose of 6cGy (scattering dose) of X-rays (left) and those from partial body irradiated animals (right) under 40 × magnification. Bar represents 50 μm. (B) Quantification of TGF-β staining in bronchial epithelial cells of each group. The whole-body irradiated group receiving a 6cGy scattering dose of X-rays, which gave similar expression levels as non-irradiated animals, was used as controls. (C) and (D) Similar to descriptions for A and B but for TGFBR1 expression, under 40 × magnification. Bar represents 20 μm. Statistical comparison between control and irradiation groups marked with asterisks (*P<0·05, Student’s t-test). Error bars indicate the s.e. of the mean (s.e.m.) for 20 independent microscopic fields from three different mice.
