Figure 5
From: Radiation-induced non-targeted response in vivo: role of the TGFβ-TGFBR1-COX-2 signalling pathway
Activation of multiple TGF- β related signalling pathways in non-targeted lung tissues. (A) Western blot data show expression of phosphorylated-Smad-2 but not phosphorylated-Rac1 in non-targeted lung tissues. (B–E) Activation of Smad-independent pathways in non-targeted lung. The kinetics of activation of ERK, JNK, NFκB and AKT in non-targeted lung tissues is shown. A total of three animals were used per time point and representative expression level from a single animal is shown. The rest of the animals of each group demonstrated similar trends. Beta-actin levels were used as loading controls in all samples.
