Table 1 Summary statistics are shown for genes with significant dose−expression relationship based on qRT−PCR measurements

From: Iodine-131 dose-dependent gene expression: alterations in both normal and tumour thyroid tissues of post-Chernobyl thyroid cancers

   

Fold change per dose category a

 

Gene

Cytoband

N

1 vs 0

95% CI

2 vs 0

95% CI

P 2 d.f. b

P 1 d.f. c

Normal tissue

ABCC3

17q22

20

2.00

0.99

4.00

2.22

1.08

4.55

0.080

0.042

C1orf9

1q24

28

1.82

1.25

2.63

1.19

0.85

1.67

0.012

0.190

C6orf62

6p22.3

28

1.32

0.99

1.75

1.47

1.12

1.92

0.018

0.004

FGFR1OP2

12p11.23

28

1.23

0.95

1.61

1.28

1.01

1.61

0.093

0.036

HEY2

6q21

27

0.91

0.56

1.47

1.61

1.04

2.50

0.058

0.050

NDOR1

9q34.3

28

1.18

0.84

1.67

1.39

1.02

1.92

0.126

0.022

STAT3

17q21.31

28

0.68

0.48

0.94

1.09

0.81

1.47

0.035

0.837

UBA3

3p14.1

28

2.22

1.25

4.00

0.90

0.53

1.54

0.018

0.931

Tumour tissue

ANKRD46

8q22.2

30

1.56

1.11

2.22

0.90

0.65

1.23

0.022

0.702

CD47

11q21

30

0.56

0.38

0.82

0.96

0.68

1.37

0.017

0.479

HNRNPH1

5q35.3

30

1.37

0.97

1.92

1.37

1.01

1.85

0.073

0.036

NDOR1

9q34.3

30

1.45

1.03

2.00

1.37

1.02

1.85

0.045

0.030

SCEL

13q22

30

0.24

0.12

0.50

0.40

0.20

0.78

<0.001

0.006

SERPINA1

14q32.1

30

0.16

0.07

0.37

0.98

0.45

2.13

<0.001

0.686

  1. aFold-change: expressed on a linear scale.
  2. b2 d.f. test: models included I-131 dose coded in three separate categories for tumour and normal tissues adjusted for age at surgery, sex, and oblast.
  3. c1 d.f. trend test: models included linear terms for dose in tumour and dose in normal tissue adjusted for age at surgery, sex, and oblast; models were fitted to all data combined.
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