Table 2 PANTHER classification of genes significantly associated with I-131 dose (after Bonferroni correction) in normal and/or tumour tissue
Normal tissue | Tumour tissue | |||
|---|---|---|---|---|
PANTHER classification | Over/under representation | P -values | Over/under representation | P -values |
Cellular component | ||||
Cytoplasm | + | 1.6E−05 | + | 2.0E−04 |
Organelle | + | 7.4E−04 | + | 9.9E−04 |
Pathway | ||||
Ubiquitin proteasome pathway | + | 6.5E−05 | ||
FGF signalling pathway | + | 1.3E−04 | ||
p53 pathway feedback loops 2 | + | 1.3E−04 | ||
EGF receptor signalling pathway | + | 1.6E−04 | ||
p53 pathway | + | 2.6E−04 | ||
Integrin signalling pathway | + | 8.2E−04 | ||
DNA replication | + | 9.1E−04 | ||
Biological process | ||||
Primary metabolic process | + | 2.0E−16 | + | 2.1E−21 |
Metabolic process | + | 8.7E−17 | + | 3.9E−21 |
Protein metabolic process | + | 4.1E−08 | + | 1.7E−13 |
Nucleobase, nucleoside, nucleotide, and nucleic acid metabolic process | + | 1.5E−13 | + | 2.7E−13 |
Unclassified | − | 2.6E−10 | − | 4.0E−09 |
Establishment or maintenance of chromatin architecture | + | 2.3E−07 | + | 2.5E−05 |
Organelle organisation | + | 2.2E−07 | + | 3.9E−05 |
Cell surface receptor linked signal transduction | − | 2.9E−05 | ||
Cell−cell signalling | − | 3.1E−05 | ||
Pattern specification process | − | 5.9E−05 | ||
Cell cycle | + | 2.7E−06 | ||
Protein transport | + | 5.3E−05 | ||
Intracellular protein transport | + | 5.3E−05 | ||
Molecular function | ||||
Nucleic acid binding | + | 3.2E−16 | + | 1.4E−21 |
Binding | + | 5.3E−16 | + | 1.6E−15 |
Structural constituent of ribosome | + | 1.3E−08 | + | 1.8E−11 |
Unclassified | − | 1.5E−08 | − | 4.9E−05 |
DNA binding | + | 7.0E−06 | + | 2.9E−05 |
Catalytic activity | + | 1.4E−05 | + | 9.0E−07 |
RNA splicing factor activity, transesterification mechanism | + | 7.7E−06 | ||
Chromatin binding | + | 1.1E−05 | ||
G-protein coupled receptor activity | − | 8.8E−08 | ||
Transferase activity | + | 1.9E−05 | ||
Receptor activity | − | 2.1E−05 | ||
Protein class | ||||
Nucleic acid binding | + | 4.3E−15 | + | 4.2E−18 |
RNA binding protein | + | 7.0E−10 | + | 7.9E−17 |
Ribosomal protein | + | 1.1E−07 | + | 4.0E−11 |
mRNA processing factor | + | 8.9E−05 | + | 6.2E−08 |
G-protein coupled receptor | − | 5.5E−07 | ||
DNA binding protein | + | 1.2E−06 | ||
Homeobox transcription factor | − | 5.8E−06 | ||
Helix-turn-helix transcription factor | − | 5.8E−06 | ||
Histone | + | 1.0E−05 | ||
Transferase | + | 1.4E−05 | ||
Signalling molecule | − | 4.0E−06 | ||
