Table 1 Cytotoxicity of SW 43, SW IV-52s and SW III-123 in human ovarian cancer cells

From: Sigma-2 receptor ligand as a novel method for delivering a SMAC mimetic drug for treating ovarian cancer

 

SKOV-3

SKOV-3

CaOV-3

CaOV-3

BG-1

BG-1

Compound

EC50±s.e. (μ M, 24 h)

EC50±s.e. (μ M, 48 h)

EC50±s.e. (μ M, 24 h)

EC50±s.e. (μ M, 48 h)

EC50±s.e. (μ M, 24 h)

EC50±s.e. (μ M, 48 h)

SW 43

25.2±0.7

19.7±0.8

15.9±1.1

14.0±0.5

24.0±0.9

24.1±2.1

SW IV-52s

>100

0.7±0.1

>100

>100

>100

>100

SW III-123

4.0±0.6

1.4±0.3

2.8±0.1

1.3±0.1

2.3±0.1

1.3±0.1