Figure 4 | British Journal of Cancer

Figure 4

From: Acquired resistance to temsirolimus in human renal cell carcinoma cells is mediated by the constitutive activation of signal transduction pathways through mTORC2

Figure 4

Changes in expression patterns of key molecules involved in signal transduction in ACHN sublines following treatment with temsirolimus. (A) Expression levels of raptor, rector, total and phosphorylated (phospho) S6 and β-actin in ACHN sublines before and after treatment with temsirolimus (10 μ M) were analysed using western blotting. (B) Expression levels of total and phosphorylated (phospho) Akt, p44/42 mitogen-activated protein kinase (MAPK) and signal transducers and activation of transcription 3 (STAT3) in ACHN sublines before and after treatment with temsirolimus (10 μ M) were analysed using western blotting.

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