Figure 5 | British Journal of Cancer

Figure 5

From: Acquired resistance to temsirolimus in human renal cell carcinoma cells is mediated by the constitutive activation of signal transduction pathways through mTORC2

Figure 5

(A ) Effects of combined treatment with temsirolimus, LY294002 and/or U0126 on the in vitro growth of ACHN sublines. Each cell line was treated with temsirolimus (10 μ M), LY294002 (10 μ M) and/or U0126 (10 μ M) and after incubation with these agents for 48 h, cell numbers of each cell line were counted in triplicate. Bars, s.d. ** and *, differ from ACHN/P (P<0.01 and P<0.05, respectively). (B) Effect of treatment with KU0063794 on the in vitro cell growth of ACHN sublines. Each cell line was treated with the indicated doses of KU0063794. After 48 h of incubation, cell growth was determined in triplicate in three independent experiments.

Back to article page