Table 5 Univariate and multivariate analyses in KRAS-WT patients

From: Serum levels of hepatocyte growth factor and epiregulin are associated with the prognosis on anti-EGFR antibody treatment in KRAS wild-type metastatic colorectal cancer

(A)

 

PFS

 

Univariate analysis

Multivariate analysis

Variables

HR

95% CI

P -value

HR

95% CI

P -value

ECOG PS

0–1

1

  

1

  

2

2.849

1.147–7.079

0.024

2.069

0.802–5.333

0.109

Gender

Male

1

     

Female

0.861

0.575–1.289

0.468

   

Age

⩽60

1

     

>60

1.028

0.692–1.528

0.890

   

Primary lesion

Colon

1

     

Rectum

1.080

0.729–1.598

0.702

   

Histological type

Well/mod

1

     

Por/sig/muc

1.473

0.845–2.566

0.172

   

Metastatic site

1

1

     

⩾2

1.041

0.676–1.603

0.856

   

Serum HGF

High

1

  

1

  

Low

0.479

0.313–0.732

<0.001

0.562

0.359–0.878

0.011

Serum EREG

High

1

  

1

  

Low

0.618

0.416–0.917

0.017

0.646

0.426–0.979

0.039

(B)

 

OS

 

Univariate analysis

Multivariate analysis

Variables

HR

95% CI

P -value

HR

95% CI

P -value

ECOG PS

0–1

1

  

1

  

2

6.637

2.611–16.870

<0.001

5.476

2.029–14.776

<0.001

Gender

Male

1

     

Female

1.377

0.833–2.275

0.212

   

Age

⩽60

1

     

>60

1.200

0.744–1.936

0.455

   

Primary lesion

Colon

1

     

Rectum

1.138

0.706–1.834

0.596

   

Histological type

Well/mod

1

     

Por/sig/muc

1.804

0.929–3.503

0.081

   

Metastatic site

1

1

     

⩾2

1.148

0.674–1.955

0.612

   

Serum HGF

High

1

  

1

  

Low

0.425

0.261–0.690

<0.001

0.447

0.267–0.747

0.002

Serum EREG

High

1

  

1

  

Low

0.621

0.416–0.917

0.035

0.605

0.365–1.001

0.050

  1. Abbreviations: CI=confidence interval; ECOG PS=Eastern Cooperative Oncology Group Performance Status; mod=moderately differentiated adenocarcinoma; muc=mucinous adenocarcinoma; PFS=progression-free survival; por=poorly differentiated adenocarcinoma; sig=signet ring cell carcinoma; well=well differentiated adenocarcinoma. Univariate and multivariate analyses in PFS and OS are shown in table (A) and (B), respectively.
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