Figure 3

SERPINB3 expression and human HCC molecular subclass. SERPINB3 expression level according to molecular subclass of HCC. SERPINB3 expression levels were extracted from publicly available transcriptome dataset (NCBI Gene Expression Omnibus accession number GSE10186) (n=97). Samples are ordered according to previously reported molecular subclasses of HCC determined by a meta-analysis of the following transcriptome datasets: S1 (activation of TGF-β/WNT pathways, EMT-like disseminative phenotype), S2 (MYC/AKT activation, AFP positivity) and S3 (preserved hepatocyte function) (Hoshida et al, 2009).