Table 1 Clinical-pathological and molecular characteristics of the 67 patients who underwent surgical resection for hepatocellular carcinoma included in the study

From: SERPINB3 is associated with TGF-β1 and cytoplasmic β-catenin expression in hepatocellular carcinomas with poor prognosis

Variable

Total ( n =67)

Low-value SERPINB3 ( n =52)

High-value SERPINB3 ( n =15)

P

Age (years), median (range)

65 (41–84)

66 (41–80)

60 (47–84)

0.3026

Females

17 (25%)

15 (29%)

2 (13%)

0.3203

Relevant comorbiditiesa

27 (40%)

21 (40%)

6 (40%)

1.0000

HCV positive

28 (42%)

23 (44%)

5 (33%)

0.5584

HBV positive

10 (15%)

7 (13%)

3 (20%)

0.6814

History of alcohol abuse

26 (39%)

20 (38%)

6 (40%)

1.0000

Clinically relevant portal hypertension

31(46%)

25 (48%)

6 (42%)

0.7699

Child–Pugh B

14 (21%)

10 (19%)

4 (27%)

0.4977

Platelets (109l−1)

131 (51–412)

129 (51–348)

132 (72–412)

0.6464

Albumin (g l−1)

38 (24–47)

38 (24–47)

39 (30–46)

0.8758

Total bilirubin (μmol l−1)

18.9 (5.0–110.7)

19 (5–45)

16 (7–110.7)

0.8427

INR

1.18 (0.91–1.83)

1.12 (0.98–1.41)

1.21 (0.91–1.83)

0.5408

Creatinine (μmol l−1)

73 (45–112)

71 (45–108)

80 (51–112)

0.0482

Na+ (mmol l−1)

137 (131–148)

139 (131–143)

138 (133–148)

0.2042

MELD

9 (6–19)

9 (6–13)

9 (7–19)

0.2042

Alpha fetoprotein (μg l−1)

19 (2–67463)

18 (2–6743)

29 (5–3731)

0.9522

BCLC Ab

40 (60%)

34 (65%)

6 (43%)

0.1335

Pathologic diameter of the largest nodule (mm)

40 (13–190)

40 (13–190)

50 (25–170)

0.2223

Pathologic number of nodules

1 (1–9)

1 (1–9)

1 (1–4)

0.4626

Multinodular HCC

15 (22%)

11 (21%)

4 (27%)

0.7284

Vascular invasion

36 (54%)

   

 Macroscopic

5 (8%)

4 (8%)

1 (7%)

1.0000

 Microscopic

31 (46%)

24 (46%)

7 (47%)

1.0000

Poorly differentiated grade

27 (40%)

22 (44%)

4 (27%)

0.3717

Intraoperative data

Operative time (min)

200 (75–405)

200 (75–405)

190 (110–290)

0.8908

Blood loss (ml)

500 (0–2500)

425 (0–2500)

750 (0–2400)

0.3495

  1. Abbreviations: BCLC=Barcelona Clinic Liver Cancer; HBV=hepatitis B virus; HCV=hepatitis C virus; INR=international normalised ratio; MELD=model end-stage liver disease score.
  2. The value in bold is statistically significant (P<0.05).
  3. aAs relevant extra-hepatic comorbidities, the presence of chronic or acute heart failure, severe obstructive or restrictive respiratory disease and severe neurological damages were included.
  4. bBCLC classification according to imaging results.
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