Table 3 Specific types and numbers of mutations found in the different groups

From: MGMT promoter hypermethylation and K-RAS, PTEN and TP53 mutations in tamoxifen-exposed and non-exposed endometrial cancer cases

Groups

Gene

Spec mut.

Type of mut.

TAM

K-RAS

14%

(4 of 29)

G>A (3 of 4)

G>T (1 of 4)

 

P53

34%

(10 of 29)

A>G (2 of 10)

A>T (1 of 10)

C>T (2 of 10)

G>A (1 of 10)

G>T (1 of 10)

Indel (3 of 10)

 

PTEN

21%

(6 of 29)

C>T (1 of 6)

Indel (5 of 6)

EC

K-RAS

5%

(2 of 37)

G>A (1 of 2)

T>C (1 of 2)

 

P53

38%

(14 of 37)

A>G (3 of 14)

C>T (6 of 14)

G>A (1 of 14)

T>A (1 of 14)

Indel (3 of 14)

 

PTEN

59%

(22 of 37)

A>C (1 of 22)

A>G (1 of 22)

A>T (2 of 22)

C>A (2 of 22)

C>G (2 of 22)

C>T (4 of 22)

G>T (2 of 22)

T>A (1 of 22)

T>G (1 of 22)

T>C (1 of 22)

Indel (5 of 22)

  1. Abbreviations: EC=unexposed to the drug; TAM=tamoxifen.
  2. The number of mutations is based on each individual mutation found in the patients, which includes multiple mutations in the same gene.
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