Table 2 Logistic regression model with a 4 knot restricted cubic spline for the association of provider delay on stage (4 week delay as reference)

From: Time from first presentation in primary care to treatment of symptomatic colorectal cancer: effect on disease stage and survival

 

Model 1

Model 2

Model 3

Model 4

 

OR (99% CI)

OR (99% CI)

OR (99% CI)

OR (99% CI)

Provider delay (weeks)

4

1.00

1.00

1.00

1.00

20

0.73 (0.50 1.07)

0.86 (0.57 1.31)

0.84 (0.54 1.32)

0.87 (0.54 1.39)

40

1.29 (0.88 1.88)

1.54 (1.03 2.32)

1.46 (0.95 2.25)

1.46 (0.93 2.31)

60

1.41 (0.92 2.17)

1.72 (1.09 2.72)

1.61 (0.99 2.60)

1.58 (0.96 2.61)

Age

 

0.97 (0.95 0.99)

0.97 (0.95 0.99)

0.97 (0.95 0.99)

Gender

Male

 

1.32 (0.89 1.95)

1.30 (0.87 1.95)

1.28 (0.85 1.92)

Female

 

1.00

1.00

1.00

Smoking status

Non-smoker

 

1.00

1.00

1.00

Current smoker

 

1.13 (0.64 1.98)

1.25 (0.69 2.25)

1.19 (0.66 2.17)

Ex-smoker

 

1.04 (0.62 1.72)

1.05 (0.62 1.78)

1.06 (0.62 1.81)

Not known

 

1.43 (0.88 2.33)

1.57 (0.95 2.60)

1.52 (0.91 2.53)

Carstairs deprivation quintile

1 (least)

 

1.00

1.00

1.00

2

 

0.72 (0.42 1.21)

0.78 (0.45 1.33)

0.77 (0.44 1.33)

3

 

1.08 (0.63 1.85)

1.18 (0.68 2.06)

1.21 (0.69 2.13)

4

 

1.16 (0.65 2.08)

1.23 (0.67 2.25)

1.22 (0.66 2.26)

5 (most)

 

0.66 (0.30 1.48)

0.67 (0.30 1.53)

0.65 (0.29 1.50)

Place of presentation

GP surgery

 

1.00

1.00

1.00

GP home visit

 

1.07 (0.59 1.94)

1.09 (0.58 2.03)

1.08 (0.58 2.04)

GP out of hours visit

 

1.85 (0.67 5.08)

2.03 (0.70 5.88)

2.03 (0.69 5.91)

Others

 

1.21 (0.35 4.11)

1.06 (0.29 3.81)

1.17 (0.32 4.28)

Missing

 

1.18 (0.40 3.48)

1.11 (0.35 3.52)

1.24 (0.38 4.02)

Charlson Index

 

1.17 (1.07 1.27)

1.18 (1.08 1.30)

1.18 (1.07 1.30)

Grade

Grade I

  

1.00

1.00

Grade II

  

6.16 (1.87 20.25)

6.16 (1.85 20.46)

Grade III/IV

  

14.29 (4.05 50.42)

14.46 (4.07 51.43)

Ungradeable

  

6.78 (1.90 24.12)

7.05 (1.96 25.32)

Emergency admission

  

0.88 (0.53 1.47)

0.82 (0.49 1.38)

Constipation

   

1.54 (0.86 2.73)

Rectal bleeding

   

0.84 (0.52 1.35)

Abdominal Pain

   

1.16 (0.73 1.84)

Anorexia

   

1.76 (0.61 5.06)

Weight loss

   

1.33 (0.65 2.73)

Abdominal Mass

   

0.83 (0.34 2.03)

  1. Abbreviations: CI=confidence interval; GP=general practitioner; OR=odds ratio.
  2. Values shown are odds ratio (99% confidence interval).
  3. Model 1: unadjusted model for time to treatment with 4 knots.
  4. Model 2: model 1 adding place of presentation, patient age, patient gender, smoking status, deprivation and Charlson index.
  5. Model 3: model 2 adding tumour grade and type of hospital admission.
  6. Model 4: model3 adding constipation, rectal bleeding, abdominal pain, anorexia, weight loss and abdominal mass.
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