Table 2 Effects on peripheral blood cytokines and angiogenic factors

From: Effect of aerobic training on the host systemic milieu in patients with solid tumours: an exploratory correlative study

 

Baseline

Month 3

 

Cytokine and angiogenic factor treatment group

Median (pg ml−1)

IQR (pg ml−1)

Median (pg ml−1)

IQR (pg ml−1)

P -value a

Hepatocyte growth factor (HGF)

Usual care

226

132–354

295

218−503

 

Aerobic training

310

209–499

236

130–426

0.008

Interleukin-4 (IL-4)

Usual care

117

77–122

120

79–138

 

Aerobic training

115

77–120

111

74–120

0.012

MIP-1 β/CCL4

Usual care

152

125–199

159

136−217

 

Aerobic training

177

123–265

163

114−205

0.034

Vascular endothelial growth factor (VEGF)

Usual care

9

1–18

11

3−16

 

Aerobic training

13

3–22

10

1–20

0.043

Tumour necrosis factor- α (TNF- α)

Usual care

2

1–3

3

1–5

 

Aerobic training

1

1–3

1

1–3

0.046

  1. Abbreviations: IQR=interquartile range; MIP-1β=macrophage inflammatory protein-1β.
  2. Data presented as median and IQR.
  3. aWilcoxon rank-sum tests indicate whether the change in cell type and group levels over time is different between usual care (n=21) and aerobic training (n=23) groups.
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