Table 3 Effects on peripheral blood leukocyte phenotype
Cell type and group | Baseline | Month 3 | Absolute mean change | Between-group mean difference | P -value a |
|---|---|---|---|---|---|
Cytotoxic T lymphocytes | |||||
CD4+ (T helper (Th) cells) | |||||
Usual care | 22.2% (7.5)b | 19.0% (9.4) | −3.2% | ||
Aerobic training | 23.6% (7.9) | 24.4% (7.7) | +0.8% | −4.0% | 0.063 |
CD4+/CD25+ (activated Th cells) | |||||
Usual care | 2.8% (2.1) | 5.0% (7.0) | +2.2% | ||
Aerobic training | 3.7% (3.4) | 3.6% (6.0) | −0.1% | 2.3% | 0.315 |
CD4+/CD45RA (naive Th cells) | |||||
Usual care | 21.9% (14.6) | 18.3% (15.5) | −3.6% | ||
Aerobic training | 19.2% (10.3) | 16.8% (9.6) | −2.4% | −1.2% | 0.890 |
CD4+/ CD45RO (memory Th cells) | |||||
Usual care | 30.1% (7.6) | 31.3% (9.3) | +1.2% | ||
Aerobic training | 30.3% (10.2) | 33.8% (10.2) | +3.5% | −2.3% | 0.269 |
CD4+/CD62L+ (central memory Th cells) | |||||
Usual care | 26.5% (11.4) | 25.6% (10.1) | −0.9% | ||
Aerobic training | 26.1% (13.1) | 26.5% (12.4) | +0.4% | −1.3% | 0.851 |
CD8+ (cytotoxic T cells) | |||||
Usual care | 48.8% (11.1) | 42.6% (12.6) | −6.2% | ||
Aerobic training | 42.9% (14.4) | 46.7% (13.8) | +3.8% | −10% | 0.101 |
CD8+/CD45RA (naive cytotoxic T cells) | |||||
Usual care | 16.3% (7.1) | 11.6% (5.0) | −4.7% | ||
Aerobic training | 13.5% (6.3) | 15.8% (6.0) | +2.3% | −7% | 0.081 |
CD8+/CD45RO (memory cytotoxic T cells) | |||||
Usual care | 9.1% (6.2) | 11.0% (5.7) | +1.9% | ||
Aerobic training | 7.0% (4.8) | 11.1% (7.2) | +4.1% | −2.2% | 0.755 |
CD8+/CD25+ (activated cytotoxic T cells) | |||||
Usual care | 3.4% (3.2) | 5.5% (2.8) | +2.1% | ||
Aerobic training | 4.7% (3.0) | 5.8% (7.4) | +1.1% | 1% | 0.337 |
B lymphocytes | |||||
CD20+ (B cells) | |||||
Usual care | 41.0% (12.4) | 46.5% (15.1) | +5.5% | ||
Aerobic training | 41.8% (16.9) | 43.0% (11.6) | +1.2% | 4.3% | 0.852 |
CD20+/CD54+ (activated B cells) | |||||
Usual care | 4.1% (1.4) | 5.9% (2.9) | +1.8% | ||
Aerobic training | 7.1% (6.5) | 7.7% (4.5) | +0.6% | 1.2% | 0.787 |
Natural killer (NK) cells | |||||
CD3+/CD56+ (NKT cells) | |||||
Usual care | 5.1% (3.5) | 4.3% (2.9) | −0.8% | ||
Aerobic training | 6.2% (5.0) | 5.7% (4.1) | −0.5% | −0.3% | 0.512 |
CD16+/ CD56+ (NK cells) | |||||
Usual care | 8.8% (5.5) | 9.8% (8.0) | +1.0% | ||
Aerobic training | 8.2% (4.4) | 9.7% (8.4) | +1.5% | −0.5% | 0.929 |
Monocytes | |||||
CD14+/CD54+ (activated monocytes) | |||||
Usual care | 8.4% (5.9) | 13.2% (10.5) | +4.8% | ||
Aerobic training | 7.9% (7.8) | 11.8% (8.8) | +3.9% | 0.9% | 0.949 |
