Figure 6 | British Journal of Cancer

Figure 6

From: Selective AKR1C3 inhibitors do not recapitulate the anti-leukaemic activities of the pan-AKR1C inhibitor medroxyprogesterone acetate

Figure 6

AKR1C3-selective inhibitors from CRT also do not recapitulate the cellular effects of MPA. (A) Dose titrations of A1, A6 or A9 were used to determine the IC50 of the selected CRT compounds, for recombinant AKR1C3 protein as determined using the PQ assay (see Materials and Methods). (B) Cumulative cell counts for HL60, K562 and KG1a after 7 days treatment with either solvent control, 0.5 mM BEZ, BAP (0.5 mM BEZ+5 μ M MPA), or 10 μ M A1/A6/A9 with 0.5 mM BEZ. Data shown is mean of a minimum of N=3 experiments±s.e.m. *P<0.01.

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