Figure 7 | British Journal of Cancer

Figure 7

From: Selective AKR1C3 inhibitors do not recapitulate the anti-leukaemic activities of the pan-AKR1C inhibitor medroxyprogesterone acetate

Figure 7

A pan-AKR1C inhibitor NCI-PI recapitulates the cellular effects of MPA. (A and B) Cumulative cell counts for HL60 and K562 after 7 days treatment with either solvent control, 0.5 mM BEZ, 5 μ M MPA, BaP (0.5 mM BEZ+5 μ M MPA), 25 μ M NCI-PI alone and 25 μ M NCI-PI+0.5 mM BEZ. (C) HL60 differentiation was assessed at day 7 by staining for CD11b and flow cytometry following treatments as above. Data shown is mean of a minimum of N=3 experiments±s.e.m. *P<0.01.

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