Figure 1

Forest plot of hazard ratios for paternity and marriage. (A) Hazard ratios (HRs) with 95% CIs of fathering a first offspring after cancer diagnosis, for all cancer survivors (n=2605, secondary malignancies excluded), subdivided into different cancer diagnoses, with the non-cancer male population as reference (n=607 668). (B) Hazard ratios with 95% CIs of marriage in the cancer survivors (n=2462), with the cancer-free male population as reference (n=603 272). (C) Hazard ratios with 95% CIs of fathering a first offspring in the married population only, in the cancer survivors (n=667) versus the male non-cancer reference population (n=203 985). The horizontal lines through the squares represent 95% CI, arrows indicate upper CI above 2.5. Solid boxes indicate HR in each cancer group with dimensions proportional to weights (inverse of s.d.). The diamonds represent the pooled HR for all cancers, with 95% CI. All analyses are adjusted for birth year of the cohort members (father) and education of parents; and for the analysis presented in C, adjustment was also made for age (of cohort member) at marriage. Age at cancer diagnosis was entered as a time-varying covariate in the extended Cox regression analysis for A and B. Only results from cancer groups containing >30 survivors are depicted. The cancer site grouping used is a modified version of the International Classification of Childhood Cancer (Kramarova and Stiller, 1996), based on ICD-O-2 and MOTNAC morphology codes and ICD-7 topography codes. The grading of CNS tumours is based on the 2007 WHO classification of tumours of the CNS (Louis et al, 2007).