Table 1 hVEGF concentrations, platelet counts and trough bevacizumab concentrations in patients 1–8

From: A functional bioassay to determine the activity of anti-VEGF antibody therapy in blood of patients with cancer

Patient number

Tumour type

VEGF concentration C1 (pg  ml−1)

VEGF concentration on-treatment (pg  ml−1)

Platelet count C1 (× 109 l−1)

Platelet count on-treatment (× 109l−1)

Bevacizumab concentration ( μ gml−1)

1

Liver

373.8

44.1

194

282

86.9

2

Ovarian

316.8

71.1

206

193

156.1

3

Neuroendocrine

178.1

72.3

157

184

74.2

4

Ovarian

2952.9

48.1

1157

1162

18.9

5

Renal

469.9

57.5

185

231

35.2

6

Ovarian

168.2

46.7

183

195

82.8

7

Breast

200

91

246

223

41.2

8

Bladder

388.5

34.5

446

445

24.6

Mean (±s.d.)

 

631.0 (±944.6)

58.2 (±18.7)

346.8 (±339.9)

364.4 (±333.4)

65.0 (±45.3)

  1. Abbreviation: VEGF=vascular endothelial growth factor.