Table 2 hVEGF concentrations, platelet counts and trough bevacizumab concentrations in patients 9–22

From: A functional bioassay to determine the activity of anti-VEGF antibody therapy in blood of patients with cancer

Patient number

Tumour type

VEGF concentration C1 (pgml−1)

VEGF concentration on-treatment (pgml−1)

Platelet count C1 (× 109l−1)

Platelet count on-treatment (× 109l−1)

Bevacizumab concentration ( μ gml−1)

9

Breast

781.2

169.9

428

372

68.3

10

Breast

425.5

129

195

248

85.3

11

Breast

1136.7

87.1

386

275

98.8

12

Breast

288.5

171.3

217

262

137.9

13

Breast

435.7

204.5

173

120

104.8

14

Breast

104.8

197.4

207

206

119.6

15

Breast

218.3

218

220

236

78.5

16

Breast

207

134.9

316

364

86.9

17

Breast

671.9

167.7

288

396

178.6

18

Breast

67.3

176.2

327

321

92.4

19

Breast

1492.3

21.3

261

419

424.1

20

Breast

3277.1

215.4

533

612

97.5

21

Breast

890.7

146.7

476

396

94.1

22

Breast

1101.6

220.1

294

259

104.1

Mean (±s.d.)

 

792.8 (±836.1)

161.4 (±55.7)

320.4 (±110.9)

320.4 (±119.5)

126.5 (±90.0)

  1. Abbreviation: VEGF=vascular endothelial growth factor.