Table 5 Excess relative risk (ERR) and relative risk (RR) of incidence and mortality of leukaemia and of lymphoma related to in utero and postnatal exposure to ionising radiation within the combined Southern Urals cohort

From: In utero exposure to radiation and haematological malignancies: pooled analysis of Southern Urals cohorts

 

N

PYAR

No. of cases

Mean exposure (Gy) a

ERR b (95% CI)

RR (95% CI)

Incidence

 Leukaemia

      

 In utero (per 100 mGy)

19 536

700 504

28

0.026

0.40 (0.07 to 2.41)

1.22 (0.78 to 1.62)

 Postnatal (per 100 mGy)

19 536

700 504

28

0.057

0.17 (−0.05 to1.24)

1.09 (0.85 to 1.28)

 Lymphoma

      

 In utero (per 100 mGy)

19 536

700 504

28

0.026

0.90 (−0.09 to 5.66)

1.16 (0.59 to 1.68)

 Postnatal (per 100 mGy)

19 536

700 504

28

0.057

0.37 (−0.05 to 3.61)

1.14 (0.85 to 1.35)

Mortality

 Leukaemia

      

 In utero (per 100 mGy)

19 956

706 269

23

0.026

−0.09 (NA to 1.33)

0.90 (0.38 to 1.45)

 Postnatal (per 100 mGy)

19 956

706 269

23

0.057

0.22 (−0.03 to 1.32)

1.13 (0.88 to 1.31)

 Lymphoma

      

 In utero (per 100 mGy)

19 956

706 269

11

0.026

NA

0.47 (0.01 to 1.65)

 Postnatal (per 100 mGy)

19 956

706 269

11

0.057

NA

0.85 (0.15 to 1.31)

  1. Abbreviations: CI=confidence interval; NA=not estimated by the Epicure software; PYAR=person-years at risk over the period of follow-up.
  2. aPerson-year-weighted mean.
  3. bModel fit under constraint that estimated parameter is greater than −1.0 for categorical analysis or (−(maximum postnatal dose)−1) for continuous analysis; lower bound of 95% CI may be estimated at boundary of parameter space.
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