Table 1A Hazards ratios of ASPN and BCR; for ASPN mRNA in Mortensen et al, and ASPN H-score in the McGill TMA. Cox analysis of ASPN mRNA and BCR in the Mortensen et al data set

From: Asporin is a stromally expressed marker associated with prostate cancer progression

  

Univariate analysis

Multivariate analysis

 

N (n)

HR

95% CI

P -value

HR

95% CI

P -value

ASPN

36 (22)

2.16

1.30–3.59

0.003

2.23

1.32–4.66

0.009

Gleason score

36 (22)

1.75

1.19–2.58

0.005

1.44

0.77–2.60

0.228

PSA

36 (22)

1.07

1.03–1.12

0.001

1.08

1.02–1.14

0.005

Stage

33 (22)

4.21

1.60–11.08

0.004

0.76

0.14–4.27

0.759

Margin

36 (22)

3.70

1.51–9.03

0.004

2.39

0.57–10.04

0.236

Age

36 (22)

0.99

0.91–1.08

0.842

0.95

0.86–1.05

0.295

  1. Abbreviations: ASPN=asporin; BCR=biochemical recurrence; CI=confidence interval; HR=hazards ratio; PSA=prostate specific antigen; TMA=tissue microarray.
  2. Cox proportional hazards ratio analysis showed that ASPN mRNA was predictive of BCR in both univariate (hazards ratio 2.16, P=0.003) and multivariate analysis (hazards ratio 2.23, P=0.009), in the Mortensen et al data set derived from microdissected normal and tumour tissue. ASPN mRNA showed a larger hazards ratio than Gleason grade in this data set. Bold indicates statistically significant values.
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