Figure 1

Flowchart of the CSi study design, follow-up triage, and ⩾CIN2 detection rate. *Of all tested samples, 4 were invalid on all HPV assays, 773 samples had a positive test result on any of the three assays, and 246 of these had biopsies taken. Of the 4124 HPV-negative women, 36 had a biopsy taken (for an unknown reason). Because of a hardware failure on the Onclarity assay, some women received their result based on CLART and HC2 only. The samples were later re-tested on Onclarity, with 36 women having a positive test result. Owing to hospital practice, these women did not receive a supplement result. The flowchart illustrates the follow-up process based on the result the women received, that is, the result that influenced their clinical management. **Non-responders remained unscreened during the whole study period; the CIN2 or worse cases detected might be symptom-related indications rather than screening. CIN=cervical intraepithelial neoplasia.