Table 2 Enrichment analysis of key transcription factors that act on genes in green module (FDR<0.05)

From: New insights into the vitamin D requirements during pregnancy

Network

GO processes

Total nodes

Seed nodes

adjusted P-value

CREB1

G1/S transition of mitotic cell cycle, metallo-and- iron-sulfur cluster assembly,

73

73

3.980E−193

c-Myc

Modulation by virus of host morphology or physiology or of other organism involved in symbiotic interaction

49

48

8.490E−124

p53

Cell cycle process cellular response to glucose starvation, negative regulation of cell cycle.

20

19

4.240E−48

ZNF143

Single-organism carbohydrate metabolic process, carbohydrate metabolic process, nucleotide metabolic process), nucleoside phosphate metabolic process, CMP-N-acetylneuraminate biosynthetic process.

19

18

1.550E−45

GCR-alpha

Cellular component organization, cellular component organization or biogenesis, cellular amino acid biosynthetic process, rhythmic process, response to arsenic-containing substance.

19

18

1.550E−45

Androgen receptor

Androgen receptor signaling pathway, intracellular steroid hormone receptor signaling pathway, positive regulation of transcription, DNA-dependent-positive regulation of RNA metabolic process, positive regulation of gene expression.

16

15

7.080E−38

SP1

Response to arsenic-containing substance, cellular response to chemical stimulus, cellular nitrogen compound metabolic process, modulation by virus of host morphology or physiology, regulation of transcription from RNA polymerase II promoter in response to hypoxia.

15

14

2.490E−35

ESR1 (nuclear)

Intracellular receptor signaling pathway, RNA metabolic process, intracellular steroid hormone receptor signaling pathway, gene expression, transcription from RNA polymerase II promoter.

15

14

2.490E−35

E2F1

cell cycle process, mitotic cell cycle, negative regulation of cellular process, cell cycle, negative regulation of biological process.

14

13

8.650E−33

  1. Top 10 significantly enriched transcription factor networks of the 202 annotated genes from the green module. For each network, the GO processes are shown along with the number of genes from the green network that are enriched within each network and the number of total nodes that define the network. Total nodes=total number of objects in the network (database); seed nodes=number of objects in green data set. Hypergeometric test adjusted for multiple comparisons using Benjamini & Hochberg (P<0.05).
  2. Cited from Ref 128, and used with permission from the publisher.
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