Figure 1
Imbalance between p75NTR and TrkB expression in the striatum of R6/1 mice. (a) Representative immunoblots showing the levels of p75NTR, TrkB and β-actin as a loading control in striatal extracts obtained from WT and R6/1 mice at 8 and 30 weeks of age. The histograms represent the relative levels of p75NTR and TrkB expressed as percentage of wild-type values. Values are given as mean±S.E.M. of 5–6 independent samples. Data was analyzed by two-way ANOVA followed by Student’s t-test. *P<0.05; **P<0.01; ***P<0.001 respect to wild-type mice. (b) Representative immunohistochemical images depicting levels of p75NTR staining in the striatum of WT and R6/1 mice at 30 weeks of age. The histogram represents the mean fluorescence intensity of p75NTR (mean±S.E.M., n=3) expressed as percentage of wild-type levels. Data was analyzed by Student’s t-test **P<0.01 respect to wild-type mice. Scale bar, 10 μm. (c) The histogram represents the mean fluorescence intensity of p75NTR staining along rostral to caudal striatal sections from WT and R6/1 mice at 30 weeks of age expressed as percentage of wild-type values (mean±S.E.M. n=3). Data was analyzed by Student’s t-test *P<0.05; **P<0.01 respect to wild-type mice
