Figure 1 | Cell Death & Disease

Figure 1

From: Differential regulation of the apoptotic machinery during megakaryocyte differentiation and platelet production by inhibitor of apoptosis protein Livin

Figure 1

Normal human MKs and platelets express Livin. (a) BM stained with secondary antibody and hematoxylin without Livin antibody as control. (b) Livin was detected in myeloid precursors and mature MKs in normal BM stained with a Livin-specific antibody. (c) Livin expression in MKs of a patient with idiopathic thrombocytopenic purpura (ITP) (original magnification, × 20). (d) The Livin protein was detected (by immunoprecipitation–western blot analysis) in platelets derived from the platelet concentrate (first two lanes). Both alternatively spliced variants of Livin, α and β, were overexpressed in LAMA-84 by transient transfection and used as a control (last two lanes) to compare endogenous Livin protein expression in platelets

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