Figure 4 | Cell Death & Disease

Figure 4

From: Expression of human cationic trypsinogen (PRSS1) in murine acinar cells promotes pancreatitis and apoptotic cell death

Figure 4

Acinar cell architecture is altered by PRSS1 transgene expression. Pancreatic tissue sections from (a) wild-type (WT), (b) PRSS1, (c) R122H and (d) N29I animals were analysed by electron microscopy. Features characteristic of the disruption of acinar cell cyto-architecture are indicated by arrows and magnified in the inset of each image: normal granules (NG), large vacuoles (LV), multi-vesicular body (MVB), lumen (LM), dilated endoplasmic reticulum (DER), decondensing granule (DG) and disruption of the apical membrane (DAM)

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