Figure 5
Analysis of cerulein-induced pancreatitis in PRSS1 transgenic mice. (a) Representative images of H&E-stained tissue sections isolated from animals from each transgenic strain and age-matched WT control, as indicated, in the absence (–CER) and presence (+ CER) of cerulein treatment (20 μg/kg). Original magnification × 200. Histological score examination of WT and transgenic animals for (b) oedema, (c) inflammation, (d) necrosis and (e) overall histopathological score.31 (f) Analysis of trypsin activity from pancreata isolated from wild-type and transgenic animals in the absence and presence of cerulein treatment. All animals analysed were 10 months old and derived from intercross mating of heterozygous animals from each transgenic strain as indicated
