Figure 5 | Cell Death & Disease

Figure 5

From: A novel androstenedione derivative induces ROS-mediated autophagy and attenuates drug resistance in osteosarcoma by inhibiting macrophage migration inhibitory factor (MIF)

Figure 5

DSTD-mediated autophagy delays cell death. The U2OS (a) and MG-63(b) cells were pretreated with 1 mM 3-MA for 1 h, and was subsequently treated with 100 μM DSTD for another 24 h. LC3 conversion and PARP cleavage were analyzed by Western blot. Cell viability and cytotoxicity in U2OS (c) and MG-63 (d) cells were measured by MTT assay and LDH release assay. **P<0.01 versus control group; *P<0.05 versus group treated with DSTD; #P<0.01 versus group treated with 3-MA

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